309 research outputs found
Production and optical properties of liquid scintillator for the JSNS experiment
The JSNS (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron
Source) experiment will search for neutrino oscillations over a 24 m short
baseline at J-PARC. The JSNS inner detector will be filled with 17 tons
of gadolinium-loaded liquid scintillator (LS) with an additional 31 tons of
unloaded LS in the intermediate -catcher and outer veto volumes.
JSNS has chosen Linear Alkyl Benzene (LAB) as an organic solvent because
of its chemical properties. The unloaded LS was produced at a refurbished
facility, originally used for scintillator production by the RENO experiment.
JSNS plans to use ISO tanks for the storage and transportation of the LS.
In this paper, we describe the LS production, and present measurements of its
optical properties and long term stability. Our measurements show that storing
the LS in ISO tanks does not result in degradation of its optical properties.Comment: 7 pages, 4 figures
Particle Probe of Horava-Lifshitz Gravity
Kehagias-Sfetsos black hole in Ho\v{r}ava-Lifshitz gravity is probed through
particle geodesics. Gravitational force of KS black hole becomes weaker than
that of Schwarzschild around horizon and interior space. Particles can be
always scattered or trapped in new closed orbits, unlike those falling forever
in Schwarzschild black. The properties of null and timelike geodesics are
classified with values of coupling constants. The precession rates of the
orbits are evaluated. The time trajectories are also classified under different
values of coupling constants for both null and timelike geodesics. Physical
phenomena that may be observable are discussed.Comment: 10 pages, 8 figure
Towards a Holographic Model of the QCD Phase Diagram
We describe the temperature-chemical potential phase diagrams of holographic
models of a range of strongly coupled gauge theories that display chiral
symmetry breaking/restoration transitions. The models are based on the
D3/probe-D7 system but with a phenomenologically chosen running
coupling/dilaton profile. We realize chiral phase transitions with either
temperature or density that are first or second order by changing the dilaton
profile. Although the models are only caricatures of QCD they show that
holographic models can capture many aspects of the QCD phase diagram and hint
at the dependence on the running coupling.Comment: 11 pages, 9 figures, v2: minor corrections, Invited contribution to
an AdS/CFT edition of Journal of Physics
Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
Therapy options at the time of recurrence of glioblastoma multiforme are often limited. We investigated whether treatment with a new intratumoral thermotherapy procedure using magnetic nanoparticles improves survival outcome. In a single-arm study in two centers, 66 patients (59 with recurrent glioblastoma) received neuronavigationally controlled intratumoral instillation of an aqueous dispersion of iron-oxide (magnetite) nanoparticles and subsequent heating of the particles in an alternating magnetic field. Treatment was combined with fractionated stereotactic radiotherapy. A median dose of 30 Gy using a fractionation of 5 × 2 Gy/week was applied. The primary study endpoint was overall survival following diagnosis of first tumor recurrence (OS-2), while the secondary endpoint was overall survival after primary tumor diagnosis (OS-1). Survival times were calculated using the Kaplan–Meier method. Analyses were by intention to treat. The median overall survival from diagnosis of the first tumor recurrence among the 59 patients with recurrent glioblastoma was 13.4 months (95% CI: 10.6–16.2 months). Median OS-1 was 23.2 months while the median time interval between primary diagnosis and first tumor recurrence was 8.0 months. Only tumor volume at study entry was significantly correlated with ensuing survival (P < 0.01). No other variables predicting longer survival could be determined. The side effects of the new therapeutic approach were moderate, and no serious complications were observed. Thermotherapy using magnetic nanoparticles in conjunction with a reduced radiation dose is safe and effective and leads to longer OS-2 compared to conventional therapies in the treatment of recurrent glioblastoma
Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles
Inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis and therapy. While surface properties such as charge are expected to play an important role in their in vivo behavior, very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution.Using a family of structurally homologous nanoparticles we have investigated how pharmacological properties including tumor uptake and biodistribution are influenced by surface charge using neutral (TEGOH), zwitterionic (Tzwit), negative (TCOOH) and positive (TTMA) nanoparticles. Nanoparticles were injected into mice (normal and athymic) either in the tail vein or into the peritoneum.Neutral and zwitterionic nanoparticles demonstrated longer circulation time via both i.p. and i.v. administration, whereas negatively and positively charged nanoparticles possessed relatively short half-lives. These pharmacological characteristics were reflected on the tumor uptake and biodistribution of the respective nanoparticles, with enhanced tumor uptake by neutral and zwitterionic nanoparticles via passive targeting
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